ABSTRACT
Linezolid is the oxazolidinone group of antibiotic with wide range of activity against the gram positive bacteria including methicillin resistant staphylococcus aureus and penicillin resistant pneumococci and vancomycin resistant enterococci. Patients who are on linezolid were reported to have reversible myelosuppression especially thrombocytopenia and anaemia. Since there are less number of studies regarding the occurrence of thrombocytopenia and the risk factors associated with it, this study was undertaken to evaluate the occurrence of linezolid induced thrombocytopenia and its association with risk factors. It was a systematic review with synthesis of available literature in English language. Articles were retrieved using search terms included “linezolid”, “and”, “or”, “thrombocytopenia” from Clinical key and PubMed, published during 2000 - 2017. Out of 16 studies retrieved, only 7 studies were analysed based on inclusion and exclusion criteria; of them, 3 were found to be prospective and retrospective cohort each and only one was retrospective cross-sectional study. The occurrence of linezolid induced thrombocytopenia range from 18-50% with normal renal function and 57% of incidence associated with renal insufficiency patients. The risk factors were found to be dose of linezolid >18-27mg/kg, body weight of subjects <55kg, creatinine clearance <88.39 to 60ml/min/1.73m2 and baseline platelet count <200*103/mm3, serum albumin concentration, serum creatinine, concomitant caspofungin therapy and duration of linezolid therapy.
ABSTRACT
Although there have been numerous studies, especially in the last few decades, on the impact of child sexual abuse (CSA) on adult survivors, there is a dearth of studies focusing on the ethical aspects of research in this area. Against this background, we reviewed the literature published between January 2000 and December 2016 on the reporting of ethical guidelines followed in research on adult survivors of CSA. We conducted a PubMed (MEDLINE) and Google Scholar search to find published research, using the keywords: “child sexual abuse”, “adult survivors”, “research”, “guidelines” and “ethics”. Our findings suggest that no particular assessment method is superior in terms of disclosure of information or reduction of distress. The use of developmentally appropriate educative materials, sensitisation, and debriefing sessions have shown some benefit in reducing distress. There is a lack of legal or social consensus on mandatory legal reporting of information provided by adult survivors of sexual abuse, with most researchers working on the premise that adults have the freedom of choice. Often, a constraint among researchers is the lack of structured training or supervision in sensitive research, which may negatively impact both the participant and the researcher. Institute ethics boards and institutions currently lack the framework to consider protocols and facilitate research, and this poses serious obstacles to fostering research. In this situation, ongoing research needs to focus on ethical aspects. Together with this, we recommend certain ethical practices drawn from various studies that may be employed for participants, researchers, and institutional ethics boards.
ABSTRACT
Introduction: The height estimation is as important as other parameters like age, sex and race especially inmedico-legal cases. The environmental and genetic factors influence the development of various parts of body.Although bilateral symmetry is a feature seen in humans, there is asymmetry in the foot length without gender orhandedness bias.Aim: To study the relationship of human height with foot length and to derive a mathematical module to predictthe height from foot length.Materials and Methods: This is a Cross-sectional study carried out in Ramaiah Medical College, Bangalore in234 individuals aged between 18 and 25 years of age. Descriptive statistics, Pearson’s correlation coefficientand linear regression were employed for the Statistical analysis of the dataResults: The overall mean foot length observed was 22.82 ±1.10 cms. There was significant difference in the meanvalues between right and left foot length which was statistically significant (P value = <0.001). The height showeda statistically significant positive correlation with left foot length in both males and females. Linear regressionequation was derived to predict height from foot length in both males and females.Conclusion: In the present study, there was a statistically significant difference in right and left side mean footlength measurements in both sexes. A positive correlation was observed between height and foot length and leftfoot length had better correlation with height in both sexes. It was concluded from further analysis that otherparameters need to be considered for better predictability of height.
ABSTRACT
Introduction: Seven cervical vertebrae constitute the skeletal framework of the neck. Along with the otheridentification points, the cardinal feature of a cervical vertebra whether typical or atypical is the presence ofForamen transversarium on the transverse process. This foramen transmits the Vertebral artery, Vertebral veinand Sympathetic nerves. These foramina are known to have variations in size, shape and numbers and may beabsent, incomplete or duplicate, which may lead to various symptoms. Their etiology is related with the variationsin the course of the Vertebral artery due to developmental reasons.Materials and methods: Three hundred dry human cervical vertebrae were collected and studied in the departmentof Anatomy, PSG Institute of Medical Sciences and Research, Coimbatore. We included all the Cervical vertebraeincluding Atlas, Axis and all other cervical vertebrae. We observed the presence, size, shape and variations ofForamen transversarium of cervical vertebrae during our study.Observations and results: Out of three hundred Cervical vertebrae, One hundred and twenty five cervical vertebrae(42%) had variations of Foramen transversarium like Complete / incomplete Accessory foramen, triple foramenon one side, absence of foramen on one side and unequal size of foramen on both the sides. The different typesof shapes of foramen transversarium were also analysed and tabulated. The areas of foramen transversariumwere measured after measuring all the diameters.Conclusion: Variations in the Foramen transversarium may indicate, the variation in the course of the Vertebralartery. The present study was important clinical implications for Head and neck and vascular surgeries. Thesevariations should be kept in our mind during surgeries on cervical spine.